Grid Layouts Rock!
Nothing trumps a reliable, easy-to-use UI. No amount of killer graphics, clever landing pages, or HTML5 showboating can equal a site that displays information clearly and concisely. Grid-based layouts are a perfect tool to do that. They can present a huge amount of content at a glance, and are easy to update. But, keeping them interesting can be a challenge. Here are some tips to bring the "wow" factor.
Keep it cohesive
One of the dangers of this layout is that it can feel cluttered. You have to give it a seamless look. Grid layouts can't feel arbitrary. Your readers' attention gets scattered if the layout looks like it's thrown together. If you are using a lot of images (and it's not a news-based site), pick ones that are similar in color scheme or composition, like Canvas Magazine does with its neutral photos. Viktoria Klein uses images that are linked by color, pattern or content to add variety while still keeping the aesthetic flow.